How to say the advice you find the hardest to take is often the most useful. in Japanese

1)良(ryou) (adj-f) good/b grade薬(kusuri) (n) medicine/pharmaceuticals/drugs/efficacious chemical/glaze/small bribeは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh口(kuchi) (n) mouth/speech/counter for people or implementsに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.苦(ku) (n) pain/anguish/suffering/distress/anxiety/worry/trouble/difficulty/hardship/duhkhaし(shi) (num) 10^24/septillion/quadrillion。(。) Japanese period "."    
ryou kusuri ha kuchi ni kurushi 。
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Translation by mookeee
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