How to say scientific knowledge has greatly advanced since the 16th century. in Japanese

1)科学的科学的(kagakuteki) (adj-na) scientific知識知識(chishiki) (n) knowledge/informationは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh16no dictionary result, likely a conjigated verbno dictionary result, likely a conjigated verb世紀世紀(seiki) (n) century/era以来以来(irai) (n-adv,n-t) since/henceforth大い大い(ooi) (pref) greater/upper/senior/a great deal/very muchに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.進歩進歩(shinpo) (n,vs) progress/advance/improvement/developmentし(shi) (num) 10^24/septillion/quadrillionてきたno dictionary result, likely a conjigated verbno dictionary result, likely a conjigated verb。(。) Japanese period "."    
kagakuteki chishiki ha 16 seiki irai ooi ni shinpo shitekita 。
Grammer form日常会話 (Casual form)Casual form (nichijoukaiwa)
everyday casual language, commonly used between friends and family.
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