How to say pollution has a disastrous effect on the ecology of a region. in Japanese

1)汚染汚染(osen) (n,vs) pollution/contamination公害公害(kougai) (n,adj-no) pollution/public nuisance/contaminationは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh地域地域(chiiki) (n) area/regionの(no) (prt) indicates possessive/nominalizes verbs and adjectives/substitutes for "ga" in subordinate phrases/indicates a confident conclusion/ indicates emotional emphasis/indicates question生態生態(seitai) (n,adj-no) mode of life/ecology/territory環境環境(kankyou) (n,adj-no) environment/circumstanceに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.壊滅的壊滅的(kaimetsuteki) (adj-na) devastating/catastrophic/crushingな(na) (prt) connects adj to noun/indicates emotion or emphasis/command/prohibition影響影響(eikyou) (n) influence/effect/to influence/to affect/to have an influence on/to impact/to have an effect onを(wo) (prt) indicates direct object of action/indicates subject of causative expression/indicates an area traversed/indicates time over which action takes place/indicates point of departure or separation of action/indicates object of desire, like, hate,与え与え(atae) (n) gift/godsendる(ru) (n) exile。(。) Japanese period "."    
osen kougai ha chiiki no seitai kankyou ni kaimetsuteki na eikyou wo atae ru 。
Grammer form日常会話 (Casual form)Casual form (nichijoukaiwa)
everyday casual language, commonly used between friends and family.
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