How to say what has estranged him from his sister? in Japanese

1)どうした(adj-pn) somehow/how/in what way/why/what kind ofわけ(n) me/you/excuse/reasonで(de) (prt) indicates location of action/at/in/indicates time of action/indicates means of action/cause of effect/by/and then/so/indicates continuing action/ indicates certainty, emphasis, etc.彼(kare) (ok) that , or something understood without naming it directly)/that person/over there/hey/eh?/thatは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh姉妹姉妹(shimai) (ik) sistersとのとの(tono) (n) feudal lord/mansion/palace仲(naka) (n) broker/brokerage/brokerage feeが(ga) (prt) indicates sentence subject/indicates possessive/but/however/still/andまずくなったno dictionary result, likely a conjigated verb(prt) indicates possessive/nominalizes verbs and adjectives/substitutes for "ga" in subordinate phrases/indicates a confident conclusion/ indicates emotional emphasis/indicates questionか(ka) (prt) indicates question/indicates choice, doubt, etc.。(。) Japanese period "."    
doushitawakede kareha shimai tono naka gamazukunattanoka 。
Grammer form日常会話 (Casual form)Casual form (nichijoukaiwa)
everyday casual language, commonly used between friends and family.
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