How to say he failed in business, and to make matters worse, his wife fell ill. in Japanese

1)彼(kare) (ok) that , or something understood without naming it directly)/that person/over there/hey/eh?/thatは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh事業事業(jigyou) (n) project/enterprise/business/industry/operations/act/deed/conductに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.失敗失敗(shippai) (n,adj-no,vs) failure/mistake/blunderしたした(shita) (n) did/a past form of the previous verb/tongue/tongue-like object/clapper/talon。(。) Japanese period "."さらにさらに(sarani) (adv,conj) furthermore/again/after all/more and more/moreover/even more困ったno dictionary result, likely a conjigated verbno dictionary result, likely a conjigated verbことにことに(kotoni) (adv) especially/particularly/unusually/above all/additionally奥さん奥さん(okusan) (n) wife/your wife/his wife/married lady/madamが(ga) (prt) indicates sentence subject/indicates possessive/but/however/still/and病気病気(byouki) (n,adj-no) illness/disease/sicknessになったになった(ninatta) (v) it became/became/turned into。(。) Japanese period "."    
kareha jigyou ni shippai shita 。 sarani komatta kotoni okusan ga byouki ninatta 。
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2)彼(kare) (ok) that , or something understood without naming it directly)/that person/over there/hey/eh?/thatは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh事業事業(jigyou) (n) project/enterprise/business/industry/operations/act/deed/conductに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.失敗失敗(shippai) (n,adj-no,vs) failure/mistake/blunder(num) 10^24/septillion/quadrillionたさらno dictionary result, likely a conjigated verbに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.困ったno dictionary result, likely a conjigated verbno dictionary result, likely a conjigated verbことにことに(kotoni) (adv) especially/particularly/unusually/above all/additionally奥さん奥さん(okusan) (n) wife/your wife/his wife/married lady/madamが(ga) (prt) indicates sentence subject/indicates possessive/but/however/still/and病気病気(byouki) (n,adj-no) illness/disease/sicknessになったになった(ninatta) (v) it became/became/turned into    
kareha jigyou ni shippai shitasarani komatta kotoni okusan ga byouki ninatta
Grammer form日常会話 (Casual form)Casual form (nichijoukaiwa)
everyday casual language, commonly used between friends and family.
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