How to say though he tried hard, nothing changed. in Japanese

1)彼の彼の(kano) (adj-pn) that努力努力(doryoku) (n,vs) great effort/exertion/endeavour/endeavor/effortにもかかわらずにもかかわらず(nimokakawarazu) (ik) in spite of/nevertheless、(、) Japanese commaすべてすべて(subete) (adj-no,n-adv,n) all/the whole/entirely/in general/wholly/overallは(ha) (int) indicating a subject/yes/indeed/well/ha!/what?/huh?/sigh以前以前(izen) (n-adv,n-t) ago/since/before/previousと(to) (prt,conj) if/when/and/with/particle used for quoting/quoting particle/ promoted pawn/ indicates question変り変り(kawari) (n) change/alteration/unusual state or event/accident/abnormality/difference/distinctionなかったなかった(nakatta) (v) didn't have。(。) Japanese period "."    
kano doryoku nimokakawarazu 、 subeteha izen to kawari nakatta 。
Grammer form日常会話 (Casual form)Casual form (nichijoukaiwa)
everyday casual language, commonly used between friends and family.
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