How to say what makes you so sad? in Japanese

1)何(nani) (int,pn,adj-no) what/ euph. for genitals or sexを(wo) (prt) indicates direct object of action/indicates subject of causative expression/indicates an area traversed/indicates time over which action takes place/indicates point of departure or separation of action/indicates object of desire, like, hate,そんなにそんなに(sonnani) (exp) so much/so/like that悲(hi) (n) karunaし(shi) (num) 10^24/septillion/quadrillionんでいるno dictionary result, likely a conjigated verbno dictionary result, likely a conjigated verbの(no) (prt) indicates possessive/nominalizes verbs and adjectives/substitutes for "ga" in subordinate phrases/indicates a confident conclusion/ indicates emotional emphasis/indicates question。(。) Japanese period "."    
naniwo sonnani kanashi ndeiruno 。
Grammer form日常会話 (Casual form)Casual form (nichijoukaiwa)
everyday casual language, commonly used between friends and family.
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Translation by mookeee
2)何(nani) (int,pn,adj-no) what/ euph. for genitals or sex(prt) indicates sentence subject/indicates possessive/but/however/still/andそんな(adj-pn) such/like that/that sort ofに(ni) (prt) indicates such things as location of person or thing, location of short-term action, etc.悲(hi) (n) karunaし(shi) (num) 10^24/septillion/quadrillionいのいの(ino) (n) one of the six administrators of a zen temple?(?) Japanese question mark    
nani gasonnani kanashi ino ?
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Translation by tommy_san
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